NS 6180

• Supplier: Tocris Bioscience
• Catalog: 4166
• Prices: $139.00, $585.00
• Sizes: 10 mg, 50 mg
• Function Type: Blocker
• Cas Number: 353262-04-1
• Chemical Name: 4-[[3-(Trifluoromethyl)phenyl]methyl]-2H-1,4-benzothiazin-3(4H)-one
• Formula: C16H12F3NOS
• Molecular Weight: 323.33
• Purity: >99 %
• Description: Potent K Ca 3.1 channel blocker (IC 50 values are 9, 14 and 15 nM for rat, human and mouse erythrocyte K Ca 3.1 channels respectively). Exhibits ~ 50% inhibition of K Ca 1.1, K V 1.3, and K V 11.1 channels, noradrenaline and dopamine transporters, L-type Ca 2+ channels and melatonin receptors at a concentration of 10 μ M. Potently inhibits IL-2 and IFN- γ production in rat lymphocytes (IC 50 ~ 50 nM); reduces DBNS-induced experimental colitis in rats.

Product References

NS6180, a new K(Ca) 3.1 channel inhibitor prevents T-cell activation and - NS6180, a new K(Ca) 3.1 channel inhibitor prevents T-cell activation and

Strobaek D, Brown DT, Jenkins DP, Chen YJ, Coleman N, Ando Y, Chiu P, Jorgensen S, Demnitz J, Wulff H, Christophersen P. Br J Pharmacol. 2013 Jan;168(2):432-44.