NS 8593 hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 4864
• Prices: $185.00, $755.00
• Sizes: 10 mg, 50 mg
• Function Type: Modulator
• Cas Number: 875755-24-1
• Chemical Name: N-[(1R)-1,2,3,4-Tetrahydro-1-naphthalenyl]-1H-benzimidazol-2-aminehydrochloride
• Formula: C17H17N3.HCl
• Molecular Weight: 299.8
• Purity: >98 %
• Description: Selective K Ca 2 (SK) channel negative modulator; inhibits SK channel currents (K d values are 0.42, 0.6 and 0.73 μ M for SK1, SK2 and SK3 respectively at 0.5 μ M Ca 2+ ). Exhibits selectivity for SK channels over K Ca 1.1 (BK), K Ca 3.1 (IK), K v , Na v and Ca v channels. Inhibits afterhyperpolarization in hippocampal slices.

Product References

Inhibitory gating modulation of small conductance Ca2+-activated K+ channels by - Inhibitory gating modulation of small conductance Ca2+-activated K+ channels by

Strobaek D, Hougaard C, Johansen TH, Sorensen US, Nielsen EO, Nielsen KS, Taylor RD, Pedarzani P, Christophersen P. Mol Pharmacol. 2006 Nov;70(5):1771-82. Epub 2006 Aug 22.

Synthesis and structure-activity relationship studies of - Synthesis and structure-activity relationship studies of

Sorensen US, Strobaek D, Christophersen P, Hougaard C, Jensen ML, Nielsen EO, Peters D, Teuber L. J Med Chem. 2008 Dec 11;51(23):7625-34.

Negative gating modulation by - Negative gating modulation by

Jenkins DP, Strobaek D, Hougaard C, Jensen ML, Hummel R, Sorensen US, Christophersen P, Wulff H. Mol Pharmacol. 2011 Jun;79(6):899-909.