NSC 109555 ditosylate

Name NSC 109555 ditosylate
Supplier Tocris Bioscience
Catalog 5112
Prices $169.00, $705.00
Sizes 10 mg, 50 mg
Function Type Inhibitor
Cas Number 66748-43-4
Chemical Name 4,4'-diacetyldiphenylureabis(guanylhydrazone)ditosylate
Formula C19H24N10O.2C7H8O3S
Molecular Weight 752.86
Purity >98 %
Description Selective, reversible, ATP-competitive Chk2 inhibitor (IC 50 = 0.2 μ M) that displays no effect on a range of other kinases including Chk1 (IC 50 > 10 μ M). Inhibits histone H1 phosphorylation (IC 50 = 0.24 μ M) and attenuates mitochondrial ATP synthesis. Exhibits antiproliferative activity in a number of leukemias in vivo .
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Product References

Actions of bis(guanylhydrazones) on isolated rat liver mitochondria. - Actions of bis(guanylhydrazones) on isolated rat liver mitochondria.

Byczkowski JZ, Salamon W, Harlos JP, Porter CW. Biochem Pharmacol. 1981 Oct;30(20):2851-60.

Potentiation of the antimitochondrial and antiproliferative effects of - Potentiation of the antimitochondrial and antiproliferative effects of

Byczkowski JZ, Zychlinski L, Porter CW. Cancer Res. 1982 Sep;42(9):3592-5.

Identification of a Bis-guanylhydrazone - Identification of a Bis-guanylhydrazone

Jobson AG, Cardellina JH 2nd, Scudiero D, Kondapaka S, Zhang H, Kim H, Shoemaker R, Pommier Y. Mol Pharmacol. 2007 Oct;72(4):876-84. Epub 2007 Jul 6.