NSC 625987

• Supplier: Tocris Bioscience
• Catalog: 4993
• Prices: $169.00, $705.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 141992-47-4
• Chemical Name: 1,4-Dimethoxy-9(10H)-acridinethione
• Formula: C15H13NO2S
• Molecular Weight: 271.33
• Purity: >98 %
• Description: Cyclin-dependent kinase (cdk) 4 inhibitor (IC 50 = 0.2 μ M at cdk4/cyclin D1). Displays > 500-fold selectivity over cdk2 (IC 50 > 100 μ M for cdc2/cyclin A, cdk2/cyclin A and cdk2/cyclin E).

Product References

The p16 status of tumor cell lines identifies small molecule inhibitors specific - The p16 status of tumor cell lines identifies small molecule inhibitors specific

Kubo A, Nakagawa K, Varma RK, Conrad NK, Cheng JQ, Lee WC, Testa JR, Johnson BE, Kaye FJ, Kelley MJ. Clin Cancer Res. 1999 Dec;5(12):4279-86.

Structural determinants of CDK4 inhibition and design of selective ATP - Structural determinants of CDK4 inhibition and design of selective ATP

McInnes C, Wang S, Anderson S, O'Boyle J, Jackson W, Kontopidis G, Meades C, Mezna M, Thomas M, Wood G, Lane DP, Fischer PM. Chem Biol. 2004 Apr;11(4):525-34.