NSC 636819

• Supplier: Tocris Bioscience
• Catalog: 2647
• Prices: $195.00, $805.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 1618672-71-1
• Chemical Name: 1,5-Bis[(1E)-2-(3,4-dichlorophenyl)ethenyl]-2,4-dinitrobenzene
• Formula: C22H12Cl4N2O4
• Molecular Weight: 510.15
• Purity: >98 %
• Description: KDM4A/KDM4B inhibitor; inhibits histone demethylase activity on H3K9me3 and induces apoptosis in LNCaP prostate cancer cells in vitro . Also negatively regulates androgen-responsive genes.

Product References

Discovery and biological evaluation of a new family of potent inhibitors of the - Discovery and biological evaluation of a new family of potent inhibitors of the

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Dual G1 and G2 phase inhibition by a novel, selective Cdc25 inhibitor - Dual G1 and G2 phase inhibition by a novel, selective Cdc25 inhibitor

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Redox regulation of Cdc25B by cell-active quinolinediones. - Redox regulation of Cdc25B by cell-active quinolinediones.

Brisson M, Nguyen T, Wipf P, Joo B, Day BW, Skoko JS, Schreiber EM, Foster C, Bansal P, Lazo JS. Mol Pharmacol. 2005 Dec;68(6):1810-20. Epub 2005 Sep 9.