NSC 687852

• Supplier: Tocris Bioscience
• Catalog: 2936
• Prices: $139.00, $585.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 1009817-63-3
• Chemical Name: 3,5-Bis[(4-nitrophenyl)methylene]-1-(1-oxo-2-propene-1-yl)-4-piperidone
• Formula: C22H17N3O6
• Molecular Weight: 419.39
• Purity: >97 %
• Description: Inhibitor of 19S regulatory particle associated deubiquitinating enzymes (DUBs), UCHL5 and USP14. Shows minimal inhibition of UCHL-1, UCHL-3, USP2, USP7, USP, BAP1 and proteasome activity. Induces apoptosis by cathepsin D-dependent caspase-cleavage (IC 50 = 0.5 μ M). Displays antitumor activity in vivo .

Product References

Induction of the lysosomal apoptosis pathway by inhibitors of the - Induction of the lysosomal apoptosis pathway by inhibitors of the

Berndtsson M, Beaujouin M, Rickardson L, Havelka AM, Larsson R, Westman J, Liaudet-Coopman E, Linder S. Int J Cancer. 2009 Mar 15;124(6):1463-9.

Inhibition of proteasome deubiquitinating activity as a new cancer therapy. - Inhibition of proteasome deubiquitinating activity as a new cancer therapy.

D'Arcy P, Brnjic S, Olofsson MH, Fryknas M, Lindsten K, De Cesare M, Perego P, Sadeghi B, Hassan M, Larsson R, Linder S. Nat Med. 2011 Nov 6;17(12):1636-40.