| Name | NSC 697923 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 1937 |
| Prices | $95.00, $399.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 343351-67-7 |
| Chemical Name | 2-[(4-Methylphenyl)sulfonyl]-5-nitrofuran |
| Formula | C11H9NO5S |
| Molecular Weight | 267.26 |
| Purity | >98 % |
| Description | Selective inhibitor of the E2 ubiquitin (Ub) conjugating enzyme UBE2N (Ubc13). Inhibits UBE2N-Ub conjugation and activity of the UBE2N-Ueva1A complex. Has no effect on UbcH5c activity. Inhibits NF- κ B activation in diffuse large B-cell lymphoma (DLBCL) cells. Inhibits cell growth and induces apoptosis in DLBCL and neuroblastoma (NB) cell lines. Supresses NB cell xenograft tumor growth in vivo . |
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Pulvino M, Liang Y, Oleksyn D, DeRan M, Van Pelt E, Shapiro J, Sanz I, Chen L, Zhao J. Blood. 2012 Aug 23;120(8):1668-77.
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