NSC 74859

• Supplier: Tocris Bioscience
• Catalog: 4858
• Prices: $149.00, $629.00
• Sizes: 10 mg, 50 mg
• Cas Number: 501919-59-1
• Chemical Name: 2-Hydroxy-4-[[2-[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino]benzoicacid
• Formula: C16H15NO7S
• Molecular Weight: 365.36
• Purity: >98 %
• Description: Selectively inhibits STAT3 DNA-binding activity in vitro (IC 50 values are 86, 160, and >300 μ M for STAT3-STAT3, STAT1-STAT3 and STAT1-STAT1 DNA-binding activity respectively). Blocks growth and induces apoptosis preferentially in tumor cells that contain persistently active STAT3 in vitro and arrests tumor growth in a murine xenograft model in vivo .

Product References

Selective chemical probe inhibitor of Stat3, identified through structure-based - Selective chemical probe inhibitor of Stat3, identified through structure-based

Siddiquee K, Zhang S, Guida WC, Blaskovich MA, Greedy B, Lawrence HR, Yip ML, Jove R, McLaughlin MM, Lawrence NJ, Sebti SM, Turkson J. Proc Natl Acad Sci U S A. 2007 May 1;104(18):7391-6. Epub 2007 Apr 26.

The STAT3 inhibitor NSC 74859 is effective in hepatocellular cancers with - The STAT3 inhibitor NSC 74859 is effective in hepatocellular cancers with

Lin L, Amin R, Gallicano GI, Glasgow E, Jogunoori W, Jessup JM, Zasloff M, Marshall JL, Shetty K, Johnson L, Mishra L, He AR. Oncogene. 2009 Feb 19;28(7):961-72.