NSC 95397

• Supplier: Tocris Bioscience
• Catalog: 2613
• Prices: $189.00, $765.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 93718-83-3
• Chemical Name: 2,3-bis[(2-Hydroxyethyl)thiol]-1,4-naphthoquinone
• Formula: C14H14O4S2
• Molecular Weight: 310.38
• Purity: >97 %
• Description: Potent and selective irreversible inhibitor of Cdc25 dual specificity phosphatases (K i values are 32, 96 and 40 nM for inhibition of Cdc25A, -B and -C respectively). Displays 125 - 180-fold selectivity over VH1-related dual-specificity phosphatase and protein tyrosine phosphatase 1b. Inhibits carcinoma cell growth and blocks G 2 /M phase transition in vitro .

Product References

Identification of a potent and selective pharmacophore for Cdc25 dual specificity - Identification of a potent and selective pharmacophore for Cdc25 dual specificity

Lazo JS, Nemoto K, Pestell KE, Cooley K, Southwick EC, Mitchell DA, Furey W, Gussio R, Zaharevitz DW, Joo B, Wipf P. Mol Pharmacol. 2002 Apr;61(4):720-8.

NAD(P)H:quinone oxidoreductase-1-dependent and -independent cytotoxicity of - NAD(P)H:quinone oxidoreductase-1-dependent and -independent cytotoxicity of

Han Y, Shen H, Carr BI, Wipf P, Lazo JS, Pan SS. J Pharmacol Exp Ther. 2004 Apr;309(1):64-70. Epub 2004 Jan 12.

Quinone-induced Cdc25A inhibition causes ERK-dependent connexin phosphorylation. - Quinone-induced Cdc25A inhibition causes ERK-dependent connexin phosphorylation.

Melchheier I, von Montfort C, Stuhlmann D, Sies H, Klotz LO. Biochem Biophys Res Commun. 2005 Feb 25;327(4):1016-23.