| Name | nTZDpa |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 5438 |
| Prices | $165.00, $685.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Agonist |
| Cas Number | 118414-59-8 |
| Chemical Name | 5-Chloro-1-[(4-chlorophenyl)methyl]-3-(phenylthio)-1H-indole-2-carboxylicacid |
| Formula | C22H15Cl2NO2S |
| Molecular Weight | 428.33 |
| Purity | >98 % |
| Description | Potent, selective non-thiazolidinedione PPAR γ partial agonist (EC 50 = 57 nM); produces ~25% maximum efficacy. Antagonizes full agonist activity by ~60% (IC 50 ~ 285 nM). Displays no activity at PPAR α or PPAR δ receptors. Produces altered receptor conformation, and regulates adipocyte development and gene expression, in a differential manner to full PPAR γ agonists. Modulates metabolism and insulin sensitivity without causing cardiac hypertrophy in mice in vivo . |
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