NU 1025

• Supplier: Tocris Bioscience
• Catalog: 2150
• Prices: $149.00, $629.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 90417-38-2
• Chemical Name: 8-Hydroxy-2-methyl-4(3H)-quinazolinone
• Formula: C9H8N2O2
• Molecular Weight: 176.17
• Purity: >99 %
• Description: Novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP). K i and IC 50 values are 48 and 400 nM respectively.

Product References

Potentiation of anti-cancer agent cytotoxicity by the potent poly(ADP-ribose) - Potentiation of anti-cancer agent cytotoxicity by the potent poly(ADP-ribose)

Bowman KJ, White A, Golding BT, Griffin RJ, Curtin NJ. Br J Cancer. 1998 Nov;78(10):1269-77.

Resistance-modifying agents. 5. Synthesis and biological properties of - Resistance-modifying agents. 5. Synthesis and biological properties of

Griffin RJ, Srinivasan S, Bowman K, Calvert AH, Curtin NJ, Newell DR, Pemberton LC, Golding BT. J Med Chem. 1998 Dec 17;41(26):5247-56.

Potentiation of temozolomide and topotecan growth inhibition and cytotoxicity by - Potentiation of temozolomide and topotecan growth inhibition and cytotoxicity by

Delaney CA, Wang LZ, Kyle S, White AW, Calvert AH, Curtin NJ, Durkacz BW, Hostomsky Z, Newell DR. Clin Cancer Res. 2000 Jul;6(7):2860-7.