NU 2058

• Supplier: Tocris Bioscience
• Catalog: 1401
• Prices: $159.00, $665.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 161058-83-9
• Chemical Name: 6-(Cyclohexylmethoxy)-9H-purin-2-amine
• Formula: C12H17N5O
• Molecular Weight: 247.3
• Purity: >99 %
• Description: Cyclin-dependent kinase (cdk) 1 and cdk2 inhibitor (K i values are 5 and 12 μ M respectively). Inhibits growth of human tumor cells in vitro (mean GI 50 = 13 μ M). Also inhibits DNA topoisomerase II ATPase activity (IC 50 = 300 μ M).

Product References

Identification of novel purine and pyrimidine cyclin-dependent kinase inhibitors - Identification of novel purine and pyrimidine cyclin-dependent kinase inhibitors

Arris CE, Boyle FT, Calvert AH, Curtin NJ, Endicott JA, Garman EF, Gibson AE, Golding BT, Grant S, Griffin RJ, Jewsbury P, Johnson LN, Lawrie AM, Newell DR, Noble ME, Sausville EA, Schultz R, Yu W. J Med Chem. 2000 Jul 27;43(15):2797-804.

Pharmacological inhibitors of cyclin-dependent kinases. - Pharmacological inhibitors of cyclin-dependent kinases.

Knockaert M, Greengard P, Meijer L. Trends Pharmacol Sci. 2002 Sep;23(9):417-25.

Substituted purine analogues define a novel structural class of catalytic - Substituted purine analogues define a novel structural class of catalytic

Jensen LH, Thougaard AV, Grauslund M, Sokilde B, Carstensen EV, Dvinge HK, Scudiero DA, Jensen PB, Shoemaker RH, Sehested M. Cancer Res. 2005 Aug 15;65(16):7470-7.