NU 7026

• Supplier: Tocris Bioscience
• Catalog: 3301
• Prices: $169.00, $705.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 154447-35-5
• Chemical Name: 2-(4-Morpholinyl)-4H-naphthol[1,2-b]pyran-4-one
• Formula: C17H15NO3
• Molecular Weight: 281.31
• Purity: >98 %
• Description: ATP-competitive inhibitor of DNA-dependent protein kinase (DNA-PK). Displays selectivity over other PIKK family enzymes (IC 50 values are 0.23, 13.0, > 100 and > 100 μ M for DNA-PK, PI3K, ATM and ATR respectively). Radiosensitizes both proliferating and quiescent mouse embryonic fibroblast cells to IR and inhibits DSB repair.

Product References

Radiosensitization and DNA repair inhibition by the combined use of novel - Radiosensitization and DNA repair inhibition by the combined use of novel

Veuger SJ, Curtin NJ, Richardson CJ, Smith GC, Durkacz BW. Cancer Res. 2003 Sep 15;63(18):6008-15.

Chlorambucil cytotoxicity in malignant B lymphocytes is synergistically increased - Chlorambucil cytotoxicity in malignant B lymphocytes is synergistically increased

Amrein L, Loignon M, Goulet AC, Dunn M, Jean-Claude B, Aloyz R, Panasci L. J Pharmacol Exp Ther. 2007 Jun;321(3):848-55. Epub 2007 Mar 9.