NVP ADW 742

Name NVP ADW 742
Supplier Tocris Bioscience
Catalog 3960
Prices $255.00, $1,045.00
Sizes 10 mg, 50 mg
Function Type Inhibitor
Cas Number 475488-23-4
Chemical Name 5-[3-(Phenylmethoxy)phenyl]-7-[trans-3-(1-pyrrolidinylmethyl)cyclobutyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Formula C28H31N5O
Molecular Weight 453.58
Purity >99 %
Description ATP-competitive inhibitor of IGF1R (IC 50 in the range of 0.1-0.2 μ M). Also inhibits c-Kit kinase activity (IC 50 in the range of 3-5 μ M). Exhibits a synergistic effect with Imatinib, enhancing the sensitivity of multiple small cell lung cancer cell lines to the chemotherapeutics etoposide (Cat. No. 1226) and carboplatin (Cat. No. 2626).
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Product References

The insulin-like growth factor-I (IGF-I) receptor kinase inhibitor NVP-ADW742, in - The insulin-like growth factor-I (IGF-I) receptor kinase inhibitor NVP-ADW742, in

Warshamana-Greene GS, Litz J, Buchdunger E, Hofmann F, Garcia-Echeverria C, Krystal GW. Mol Cancer Ther. 2004 May;3(5):527-35.

The insulin-like growth factor-I receptor kinase inhibitor, NVP-ADW742, - The insulin-like growth factor-I receptor kinase inhibitor, NVP-ADW742,

Warshamana-Greene GS, Litz J, Buchdunger E, Garcia-Echeverria C, Hofmann F, Krystal GW. Clin Cancer Res. 2005 Feb 15;11(4):1563-71.

The insulin-like growth factor-I receptor kinase inhibitor NVP-ADW742 sensitizes - The insulin-like growth factor-I receptor kinase inhibitor NVP-ADW742 sensitizes

Zhou H, Rao J, Lin J, Yin B, Sheng H, Lin F, Zhang N, Yang L. Oncol Rep. 2011 Jun;25(6):1565-71.