NVP BHG 712

• Supplier: Tocris Bioscience
• Catalog: 5247
• Prices: $105.00
• Sizes: 1 mg
• Function Type: Inhibitor
• Cas Number: 940310-85-0
• Chemical Name: 4-Methyl-3-[[1-methyl-6-(3-pyridinyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]amino]-N-[3-(trifluoromethyl)phenyl]benzamidetrifluoroacetate
• Formula: C26H20F3N7O.CF3CO2H
• Molecular Weight: 617.5
• Purity: >98 %
• Description: Selective inhibitor of EphB4 kinase; exhibits selectivity for EphB4 over more than 40 other kinases in vitro , including FGFR3. Inhibits EphB4 autophosphorylation in transiently transfected HEK 293 cells. Also inhibits VEGF-induced angiogenesis in vivo ; thought to inhibit EphB4 forward signaling. Orally active.

Product References

The small molecule specific EphB4 kinase inhibitor NVP-BHG712 inhibits VEGF - The small molecule specific EphB4 kinase inhibitor NVP-BHG712 inhibits VEGF

Martiny-Baron G, Holzer P, Billy E, Schnell C, Brueggen J, Ferretti M, Schmiedeberg N, Wood JM, Furet P, Imbach P. Angiogenesis. 2010 Sep;13(3):259-67.

Podocyte EphB4 signaling helps recovery from glomerular injury. - Podocyte EphB4 signaling helps recovery from glomerular injury.

Wnuk M, Hlushchuk R, Janot M, Tuffin G, Martiny-Baron G, Holzer P, Imbach-Weese P, Djonov V, Huynh-Do U. Kidney Int. 2012 Jun;81(12):1212-25.