NVP CXCR2 20

Name NVP CXCR2 20
Supplier Tocris Bioscience
Catalog 4405
Prices $149.00, $629.00
Sizes 10 mg, 50 mg
Function Type Antagonist
Cas Number 1029521-30-9
Chemical Name 4-Cyclopropyl-2-[[(2,3-difluorophenyl)methyl]thio]-1,6-dihydro-6-oxo5-pyrimidinecarbonitrile
Formula C15H11F2N3OS
Molecular Weight 319.33
Purity >98 %
Description Potent and selective CXCR2 antagonist (IC 50 = 40 nM). Exhibits selectivity for CXCR2 over a panel of 49 other GPCRs. Orally bioavailable.
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Product References

NVP-DPP728 (1-[[[2-[(5-cyanopyridin-2-yl)amino]ethyl]amino]acetyl]-2-cyano-(S)- - NVP-DPP728 (1-[[[2-[(5-cyanopyridin-2-yl)amino]ethyl]amino]acetyl]-2-cyano-(S)-

Hughes TE, Mone MD, Russell ME, Weldon SC, Villhauer EB. Biochemistry. 1999 Sep 7;38(36):11597-603.

Dipeptidyl peptidase IV inhibitor NVP-DPP728 ameliorates early insulin response - Dipeptidyl peptidase IV inhibitor NVP-DPP728 ameliorates early insulin response

Mitani H, Takimoto M, Kimura M. Jpn J Pharmacol. 2002 Apr;88(4):451-8.

Long-term inhibition of dipeptidyl peptidase IV improves glucose tolerance and - Long-term inhibition of dipeptidyl peptidase IV improves glucose tolerance and

Reimer MK, Holst JJ, Ahren B. Eur J Endocrinol. 2002 May;146(5):717-27.