O-2050

• Supplier: Tocris Bioscience
• Catalog: 2288
• Prices: $269.00
• Sizes: 10 mg
• Function Type: Antagonist
• Cas Number: 851320-29-1
• Chemical Name: (6aR,10aR)-1-Hydroxy-3-(1-Methanesulfonylamino-4-hexyn-6-yl)-6a,7,10,10a-tetrahydro-6,6,9-trimethyl-6H-dibenzo[b,d]pyran
• Formula: C23H31NO4S
• Molecular Weight: 417.56
• Purity: >97 %
• Description: Originally defined as a high affinity cannabinoid CB 1 receptor silent antagonist. Acts as a partial agonist in inhibiting forksolin-induced cyclic AMP stimulation (EC 50 = 40.4 nM). Decreases food intake and stimulates locomotor activity in rodents. Antagonizes effects of CP55,940 (Cat. No. 0949) in vitro .

Product References

Suppression of feeding, drinking, and locomotion by a putative cannabinoid - Suppression of feeding, drinking, and locomotion by a putative cannabinoid

Gardner A, Mallet PE. Eur J Pharmacol. 2006 Jan 13;530(1-2):103-6. Epub 2005 Dec 27.

Structural and pharmacological analysis of O-2050, a putative neutral cannabinoid - Structural and pharmacological analysis of O-2050, a putative neutral cannabinoid

Wiley JL, Breivogel CS, Mahadevan A, Pertwee RG, Cascio MG, Bolognini D, Huffman JW, Walentiny DM, Vann RE, Razdan RK, Martin BR. Eur J Pharmacol. 2011 Jan 25;651(1-3):96-105.