Obtustatin

• Supplier: Tocris Bioscience
• Catalog: 2445
• Prices: $279.00
• Sizes: 100 µg
• Function Type: Inhibitor
• Formula: C184H284N52O57S8
• Molecular Weight: 4393.07
• Description: Highly potent integrin α 1 β 1 inhibitor (IC 50 = 0.8 nM for α 1 β 1 binding to type IV collagen). Selective for α 1 β 1 over α 2 β 1 , α IIb β 3 , α v β 3 , α 4 β 1 , α 5 β 6 , α 9 β 1 and α 4 β 7 . Inhibits FGF2-stimulated angiogenesis in the chicken chorioallantoic model. Displays antitumor efficacy in a synergistic mouse model of Lewis lung carcinoma; blocks human melanoma growth in nude mice.

Product References

Obtustatin: a potent selective inhibitor of alpha1beta1 integrin in vitro and - Obtustatin: a potent selective inhibitor of alpha1beta1 integrin in vitro and

Marcinkiewicz C, Weinreb PH, Calvete JJ, Kisiel DG, Mousa SA, Tuszynski GP, Lobb RR. Cancer Res. 2003 May 1;63(9):2020-3.

Amino acid sequence and homology modeling of obtustatin, a novel - Amino acid sequence and homology modeling of obtustatin, a novel

Moreno-Murciano MP, Monleon D, Calvete JJ, Celda B, Marcinkiewicz C. Protein Sci. 2003 Feb;12(2):366-71.

Angiostatic activity of obtustatin as alpha1beta1 integrin inhibitor in - Angiostatic activity of obtustatin as alpha1beta1 integrin inhibitor in

Brown MC, Staniszewska I, Del Valle L, Tuszynski GP, Marcinkiewicz C. Int J Cancer. 2008 Nov 1;123(9):2195-203.