Ochratoxin A

Name Ochratoxin A
Supplier Tocris Bioscience
Catalog 4664
Prices $95.00
Sizes 1 mg
Cas Number 303-47-9
Chemical Name N-[[(3R)-5-Chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl]carbonyl]-L-phenylalanine
Formula C20H18ClNO6
Molecular Weight 403.82
Purity >99 %
Description Mycotoxin that increases activity of the endoplasmic reticulum ATP-dependent calcium pump. Induces JNK activation and apoptosis in MDCK-C7 cells at nanomolar concentrations. Stimulates lipid peroxidation.
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Product References

Mechanism of action of ochratoxin A. - Mechanism of action of ochratoxin A.

Dirheimer G, Creppy EE. IARC Sci Publ. 1991;(115):171-86.

Role of cytochrome P-450 in ochratoxin A-stimulated lipid peroxidation. - Role of cytochrome P-450 in ochratoxin A-stimulated lipid peroxidation.

Omar RF, Rahimtula AD, Bartsch H. J Biochem Toxicol. 1991 Fall;6(3):203-9.

Alterations in ATP-dependent calcium uptake by rat renal cortex microsomes - Alterations in ATP-dependent calcium uptake by rat renal cortex microsomes

Chong X, Rahimtula AD. Biochem Pharmacol. 1992 Oct 6;44(7):1401-9.

Ochratoxin A induces JNK activation and apoptosis in MDCK-C7 cells at nanomolar - Ochratoxin A induces JNK activation and apoptosis in MDCK-C7 cells at nanomolar

Gekle M, Schwerdt G, Freudinger R, Mildenberger S, Wilflingseder D, Pollack V, Dander M, Schramek H. J Pharmacol Exp Ther. 2000 Jun;293(3):837-44.