Ocinaplon

• Supplier: Tocris Bioscience
• Catalog: 1291
• Prices: $189.00, $765.00
• Sizes: 10 mg, 50 mg
• Function Type: Modulator
• Cas Number: 96604-21-6
• Chemical Name: 2-Pyridinyl[7-(4-pyridinyl)pyrazolo[1,5-a]pyrimidin-3-yl]methanone
• Formula: C17H11N5O
• Molecular Weight: 301.3
• Purity: >98 %
• Description: Modulator of GABA A receptors. Displays modest selectivity for GABA A α 1 receptors; displays partial agonist activity at α 2-, α 3- and α 5-containing receptors. Exhibits anxiolytic activity.

Product References

Selective anxiolysis produced by ocinaplon, a GABA(A) receptor modulator. - Selective anxiolysis produced by ocinaplon, a GABA(A) receptor modulator.

Lippa A, Czobor P, Stark J, Beer B, Kostakis E, Gravielle M, Bandyopadhyay S, Russek SJ, Gibbs TT, Farb DH, Skolnick P. Proc Natl Acad Sci U S A. 2005 May 17;102(20):7380-5. Epub 2005 May 3.

Comparative cue generalization profiles of L-838, 417, SL651498, zolpidem, - Comparative cue generalization profiles of L-838, 417, SL651498, zolpidem,

Mirza NR, Rodgers RJ, Mathiasen LS. J Pharmacol Exp Ther. 2006 Mar;316(3):1291-9. Epub 2005 Dec 8.

GABAA receptors as targets for novel anxiolytic drugs. - GABAA receptors as targets for novel anxiolytic drugs.

Rupprecht R, Eser D, Zwanzger P, Moller HJ. World J Biol Psychiatry. 2006;7(4):231-7.