Olmesartan

• Supplier: Tocris Bioscience
• Catalog: 4110
• Prices: $105.00
• Sizes: 50 mg
• Function Type: Antagonist
• Cas Number: 144689-24-7
• Chemical Name: 4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylicacid
• Formula: C24H26N6O3
• Molecular Weight: 446.5
• Purity: >99 %
• Description: Potent angiotensin II type I (AT 1 ) receptor antagonist (IC 50 = 6.7 nM at hAT 1 receptors). Improves cognitive function in a mouse model of hypertension- and hyperlipidemia-associated cognitive decline; ameliorates arterial stiffness in a rat model of chronic renal failure. Metabolite of Olmesartan medoxomil (Cat. No. 4620).

Product References

Inhibition of cognitive decline in mice fed a high-salt and cholesterol diet by - Inhibition of cognitive decline in mice fed a high-salt and cholesterol diet by

Mogi M, Tsukuda K, Li JM, Iwanami J, Min LJ, Sakata A, Fujita T, Iwai M, Horiuchi M. Neuropharmacology. 2007 Dec;53(8):899-905. Epub 2007 Sep 22.

In vitro antagonistic properties of a new angiotensin type 1 receptor blocker, - In vitro antagonistic properties of a new angiotensin type 1 receptor blocker,

Ojima M, Igata H, Tanaka M, Sakamoto H, Kuroita T, Kohara Y, Kubo K, Fuse H, Imura Y, Kusumoto K, Nagaya H. J Pharmacol Exp Ther. 2011 Mar;336(3):801-8.

Effects of olmesartan on arterial stiffness in rats with chronic renal failure. - Effects of olmesartan on arterial stiffness in rats with chronic renal failure.

Chuang YC, Wu MS, Su YK, Fang KM. Cardiovasc Diabetol. 2012 Jun 13;11:66.