Olmesartan medoxomil

• Supplier: Tocris Bioscience
• Catalog: 4616
• Prices: $105.00
• Sizes: 50 mg
• Function Type: Antagonist
• Cas Number: 144689-63-4
• Chemical Name: 4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-Imidazole-5-carboxylicacid-(5-methyl-2-oxo-1,3-dioxol-4-yl)methylester
• Formula: C29H30N6O6
• Molecular Weight: 558.59
• Purity: >98 %
• Description: Prodrug metabolised in vivo to Olmesartan (Cat. No. 4616), a selective non-peptide angiotensin II type I receptor (AT 1 ) antagonist. Selectively inhibits angiotensin II binding to AT 1 receptors in bovine adrenal cortical membranes (IC 50 = 7.7 nM), with no effect on AT 2 receptors.

Product References

Pharmacology of CS-866, a novel nonpeptide angiotensin II receptor antagonist. - Pharmacology of CS-866, a novel nonpeptide angiotensin II receptor antagonist.

Mizuno M, Sada T, Ikeda M, Fukuda N, Miyamoto M, Yanagisawa H, Koike H. Eur J Pharmacol. 1995 Oct 16;285(2):181-8.

Effects of angiotensin AT1 receptor antagonist on volume overload-induced cardiac - Effects of angiotensin AT1 receptor antagonist on volume overload-induced cardiac

Kim S, Sada T, Mizuno M, Ikeda M, Yano M, Miura K, Yamanaka S, Koike H, Iwao H. Hypertens Res. 1997 Jun;20(2):133-42.