Olomoucine

• Supplier: Tocris Bioscience
• Catalog: 4620
• Prices: $149.00, $629.00
• Sizes: 5 mg, 25 mg
• Function Type: Inhibitor
• Cas Number: 101622-51-9
• Chemical Name: 6-(Benzylamino)-2-(2-hydroxyethylamino)-9-methylpurine
• Formula: C15H18N6O
• Molecular Weight: 298.35
• Description: Cyclin-dependent kinase inhibitor that competes for the ATP binding site of the kinase. Selectively inhibits cdc2/cyclin B (IC 50 = 7 μ M), cdk2/cyclin A (IC 50 = 7 μ M), cdk2/cyclin E (IC 50 = 7 μ M), cdk/p35 kinase (IC 50 = 3 μ M) and ERK1/MAP kinase (IC 50 = 25 μ M). Arrests human fibroblasts in the G1 phase.

Product References

Inhibition of cyclin-dependent kinases by purine analogues. - Inhibition of cyclin-dependent kinases by purine analogues.

Vesely J, Havlicek L, Strnad M, Blow JJ, Donella-Deana A, Pinna L, Letham DS, Kato J, Detivaud L, Leclerc S, et al.. Eur J Biochem. 1994 Sep 1;224(2):771-86.

Cellular effects of olomoucine, an inhibitor of cyclin-dependent kinases. - Cellular effects of olomoucine, an inhibitor of cyclin-dependent kinases.

Abraham RT, Acquarone M, Andersen A, Asensi A, Belle R, Berger F, Bergounioux C, Brunn G, Buquet-Fagot C, Fagot D, et al.. Biol Cell. 1995;83(2-3):105-20.

The cyclin-dependent kinase inhibitors olomoucine and roscovitine arrest human - The cyclin-dependent kinase inhibitors olomoucine and roscovitine arrest human

Alessi F, Quarta S, Savio M, Riva F, Rossi L, Stivala LA, Scovassi AI, Meijer L, Prosperi E. Exp Cell Res. 1998 Nov 25;245(1):8-18.