Oltipraz

• Supplier: Tocris Bioscience
• Catalog: 4241
• Prices: $79.00, $335.00
• Sizes: 10 mg, 50 mg
• Function Type: Activator
• Cas Number: 64224-21-1
• Chemical Name: 4-Methyl-5-(2-pyrazinyl)-3H-1,2-dithiole-3-thione
• Formula: C8H6N2S3
• Molecular Weight: 226.34
• Purity: >99 %
• Description: Nrf2 activator; activates Nrf, which binds to antioxidant response elements (AREs) and induces Phase-I and -II drug-metabolizing enzymes including CYP2B and NQO1. Also increases mRNA levels of multiple hepatic xenobiotic transporters. Elevates expression of genes encoding anti-oxidant and multidrug resistance-associated proteins. Displays chemopreventive activity.

Product References

Oxidative and electrophilic stress induces multidrug resistance-associated - Oxidative and electrophilic stress induces multidrug resistance-associated

Maher JM, Dieter MZ, Aleksunes LM, Slitt AL, Guo G, Tanaka Y, Scheffer GL, Chan JY, Manautou JE, Chen Y, Dalton TP, Yamamoto M, Klaassen CD. Hepatology. 2007 Nov;46(5):1597-610.

Induction of Nrf2-regulated genes by 3H-1, 2-dithiole-3-thione through the ERK - Induction of Nrf2-regulated genes by 3H-1, 2-dithiole-3-thione through the ERK

Manandhar S, Cho JM, Kim JA, Kensler TW, Kwak MK. Eur J Pharmacol. 2007 Dec 22;577(1-3):17-27. Epub 2007 Aug 23.

Induction of drug metabolism enzymes and transporters by oltipraz in rats. - Induction of drug metabolism enzymes and transporters by oltipraz in rats.

Merrell MD, Augustine LM, Slitt AL, Cherrington NJ. J Biochem Mol Toxicol. 2008 Mar-Apr;22(2):128-35.