Omeprazole

• Supplier: Tocris Bioscience
• Catalog: 1797
• Prices: $75.00
• Sizes: 50 mg
• Function Type: Inhibitor
• Cas Number: 73590-58-6
• Chemical Name: 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole
• Formula: C17H19N3O3S
• Molecular Weight: 345.42
• Purity: >99 %
• Description: H + ,K + -ATPase inhibitor (IC 50 = 5.8 μ M) that displays antisecretory and antiulcer activity. Inhibits gastric acid secretion (IC 50 = 0.16 μ M for histamine-induced acid formation) and reduces gastric lesion formation induced by a variety of ulcerative stimuli. Antibacteral against Helicobacter pylori in vitro . Also inhibits CYP2C19, CYP2C9 and CYP3A (K i values are 3.1, 40.1 and 84.4 μ M respectively) and blocks swelling-dependent chloride channels (ICIswell).

Product References

Antisecretory and antiulcer activities of a novel proton pump inhibitor AG-1749 - Antisecretory and antiulcer activities of a novel proton pump inhibitor AG-1749

Satoh H, Inatomi N, Nagaya H, Inada I, Nohara A, Nakamura N, Maki Y. J Pharmacol Exp Ther. 1989 Feb;248(2):806-15.

Proton pump inhibitors. Pharmacology and rationale for use in gastrointestinal - Proton pump inhibitors. Pharmacology and rationale for use in gastrointestinal

Richardson P, Hawkey CJ, Stack WA. Drugs. 1998 Sep;56(3):307-35.

The gastric H,K-ATPase blocker lansoprazole is an inhibitor of chloride channels. - The gastric H,K-ATPase blocker lansoprazole is an inhibitor of chloride channels.

Schmarda A, Dinkhauser P, Gschwentner M, Ritter M, Furst J, Scandella E, Woll E, Laich A, Rossmann H, Seidler U, Lang F, Paulmichl M. Br J Pharmacol. 2000 Feb;129(3):598-604.