ONO 1078

• Supplier: Tocris Bioscience
• Catalog: 2891
• Prices: $95.00
• Sizes: 50 mg
• Function Type: Antagonist
• Cas Number: 103177-37-3
• Chemical Name: N-[4-Oxo-2-(1H-tetrazol-5-yl)-4H-1-benzopyran-8-yl]-4(4-phenylbutoxy)benzamide
• Formula: C27H23N5O4
• Molecular Weight: 481.5
• Purity: >99 %
• Description: Selective cysteinyl leukotriene receptor 1 (CysLT 1 ) antagonist (IC 50 values are ~ 4 - 7 and 3620 nM for CysLT 1 and CysLT 2 respectively). Inhibits contraction of airway smooth muscle, microvascular leakage into airways and eosinophil infiltration. Can decrease symptoms of bronchial asthma.

Product References

Characterization of the human cysteinyl leukotriene CysLT1 receptor. - Characterization of the human cysteinyl leukotriene CysLT1 receptor.

Lynch KR, O'Neill GP, Liu Q, Im DS, Sawyer N, Metters KM, Coulombe N, Abramovitz M, Figueroa DJ, Zeng Z, Connolly BM, Bai C, Austin CP, Chateauneuf A, Stocco R, Greig GM, Kargman S, Hooks SB, Hosfield E, Williams DL Jr, Ford-Hutchinson AW, Caskey CT, Evans JF. Nature. 1999 Jun 24;399(6738):789-93.

Characterization of the human cysteinyl leukotriene 2 receptor. - Characterization of the human cysteinyl leukotriene 2 receptor.

Heise CE, O'Dowd BF, Figueroa DJ, Sawyer N, Nguyen T, Im DS, Stocco R, Bellefeuille JN, Abramovitz M, Cheng R, Williams DL Jr, Zeng Z, Liu Q, Ma L, Clements MK, Coulombe N, Liu Y, Austin CP, George SR, O'Neill GP, Metters KM, Lynch KR, Evans JF. J Biol Chem. 2000 Sep 29;275(39):30531-6.

Inhibition of human eosinophil activation by a cysteinyl leukotriene receptor - Inhibition of human eosinophil activation by a cysteinyl leukotriene receptor

Suzuki M, Kato M, Kimura H, Fujiu T, Morikawa A. J Asthma. 2003 Jun;40(4):395-404.