ONO 4817

• Supplier: Tocris Bioscience
• Catalog: 4530
• Prices: $269.00
• Sizes: 10 mg
• Function Type: Inhibitor
• Cas Number: 223472-31-9
• Chemical Name: N-[(1S,3S)-1-[(Ethoxymethoxy)methyl]-4-(hydroxyamino)-3-methyl-4-oxobutyl]-4-phenoxybenzamide
• Formula: C22H28N2O6
• Molecular Weight: 416.47
• Purity: >99 %
• Description: Broad spectrum MMP inhibitor; K i values are 0.45, 0.73, 1.1, 1.1, 2.1, 42 and 2500 nM for MMP-12, MMP-2, MMP-8, MMP-13, MMP-9, MMP-3 and MMP-7 respectively and IC 50 = 1600 nM for MMP-1). Displays no activity at other proteases up to a concentration of 100 μ M. Exhibits antiangiogenic and anti-invasive properties on lung metastasis of murine renal cell carcinoma.

Product References

ONO-4817, an orally active matrix metalloproteinase inhibitor, prevents - ONO-4817, an orally active matrix metalloproteinase inhibitor, prevents

Yamada A, Uegaki A, Nakamura T, Ogawa K. Inflamm Res. 2000 Apr;49(4):144-6.

Effect of a matrix metalloproteinase inhibitor (ONO-4817) on lung metastasis of - Effect of a matrix metalloproteinase inhibitor (ONO-4817) on lung metastasis of

Muraishi Y, Mitani N, Fuse H, Saiki I. Anticancer Res. 2001 Nov-Dec;21(6A):3845-52.

Role of matrix metalloproteinases in intestinal inflammation. - Role of matrix metalloproteinases in intestinal inflammation.

Medina C, Radomski MW. J Pharmacol Exp Ther. 2006 Sep;318(3):933-8. Epub 2006 Apr 27.