ONO 6818

• Supplier: Tocris Bioscience
• Catalog: 2628
• Prices: $289.00
• Sizes: 10 mg
• Function Type: Inhibitor
• Cas Number: 208848-19-5
• Chemical Name: 5-Amino-N-[1-[[5-(1,1-dimethylethyl)-1,3,4-oxadiazol-2-yl]carbonyl]-2-methylpropyl]-6-oxo-2-phenyl-1(6H)-pyrimidineacetamide
• Formula: C23H28N6O4
• Molecular Weight: 452.51
• Purity: >98 %
• Description: High affinity and selective human neutrophil elastase 1 (HNE1) inhibitor (K i = 12 nM). Exhibits >100-fold less activity at other related proteases including trypsin, pancreatic elastase, collagenase and murine macrophage elastase. Inhibits HNE-induced lung hemorrhaging and suppresses leukocyte levels in an in vivo model of COPD. Orally active.

Product References

Modulators of the glycine site on NMDA receptors, D-serine and ALX 5407, display - Modulators of the glycine site on NMDA receptors, D-serine and ALX 5407, display

Lipina T, Labrie V, Weiner I, Roder J. Psychopharmacology (Berl). 2005 Apr;179(1):54-67. Epub 2005 Mar 10.

ONO-8130, a selective prostanoid EP1 receptor antagonist, relieves bladder pain - ONO-8130, a selective prostanoid EP1 receptor antagonist, relieves bladder pain

Miki T, Matsunami M, Nakamura S, Okada H, Matsuya H, Kawabata A. Pain. 2011 Jun;152(6):1373-81.