ONO AE3 208

• Supplier: Tocris Bioscience
• Catalog: 5406
• Prices: $195.00, $805.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 402473-54-5
• Chemical Name: 4-Cyano-2-[[2-(4-fluoro-1-naphthalenyl)-1-oxopropyl]amino]benzenebutanoicacid
• Formula: C24H21FN2O3
• Molecular Weight: 404.43
• Purity: >98 %
• Description: High affinity and selective EP 4 receptor antagonist (K i values are 1.3, 30, 790 and 2400 nM for EP 4 , EP 3 , FP and TP receptors respectively). Displays no affinity for EP 1 , EP 2 , DP or IP receptors (K i >10 μ M). Inhibits PGE 2 -induced IL-8 production in colonic epithelial caco-2 cells and attenuates PGE 2 inhibition of natural killer T cell activation. Suppresses recovery from experimentally-induced colitis and stimulates CD4 + T cell proliferation in C57BL/6 mice. Also reduces metastasis of mammary tumor cells in a murine model of breast cancer. Orally active.

Product References

The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell - The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell

Kabashima K, Saji T, Murata T, Nagamachi M, Matsuoka T, Segi E, Tsuboi K, Sugimoto Y, Kobayashi T, Miyachi Y, Ichikawa A, Narumiya S. J Clin Invest. 2002 Apr;109(7):883-93.

Prostaglandin E receptor EP4 antagonism inhibits breast cancer metastasis. - Prostaglandin E receptor EP4 antagonism inhibits breast cancer metastasis.

Ma X, Kundu N, Rifat S, Walser T, Fulton AM. Cancer Res. 2006 Mar 15;66(6):2923-7.

Prostaglandin E(2) couples through EP(4) prostanoid receptors to induce IL-8 - Prostaglandin E(2) couples through EP(4) prostanoid receptors to induce IL-8

Dey I, Giembycz MA, Chadee K. Br J Pharmacol. 2009 Feb;156(3):475-85.

Exosome-like nanoparticles from intestinal mucosal cells carry prostaglandin E2 - Exosome-like nanoparticles from intestinal mucosal cells carry prostaglandin E2

Deng ZB, Zhuang X, Ju S, Xiang X, Mu J, Liu Y, Jiang H, Zhang L, Mobley J, McClain C, Feng W, Grizzle W, Yan J, Miller D, Kronenberg M, Zhang HG. J Immunol. 2013 Apr 1;190(7):3579-89.