OPC 21268

Name OPC 21268
Supplier Tocris Bioscience
Catalog 5143
Prices $225.00, $925.00
Sizes 10 mg, 50 mg
Function Type Antagonist
Cas Number 131631-89-5
Chemical Name N-[3-[4-[[4-(3,4-Dihydro-2-oxo-1(2H)quinolinyl)-1-piperidinyl]carbonyl]phenoxy]propyl]-acetamide
Formula C26H31N3O4
Molecular Weight 449.54
Purity >98 %
Description Nonpeptide vasopressin V 1 receptor antagonist. Displays greater affinity for rat V 1 than human V 1 (K i values are 25 and 8800 nM respectively). Exhibits 1000-fold selectivity for V 1 receptors over V 2 receptors. Orally active.
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Product References

OPC-21268, an orally effective, nonpeptide vasopressin V1 receptor antagonist. - OPC-21268, an orally effective, nonpeptide vasopressin V1 receptor antagonist.

Yamamura Y, Ogawa H, Chihara T, Kondo K, Onogawa T, Nakamura S, Mori T, Tominaga M, Yabuuchi Y. Science. 1991 Apr 26;252(5005):572-4.

Effects of OPC-21268, an orally effective vasopressin V1 receptor antagonist in - Effects of OPC-21268, an orally effective vasopressin V1 receptor antagonist in

Imaizumi T, Harada S, Hirooka Y, Masaki H, Momohara M, Takeshita A. Hypertension. 1992 Jul;20(1):54-8.

A molecular model of agonist and nonpeptide antagonist binding to the human V(1) - A molecular model of agonist and nonpeptide antagonist binding to the human V(1)

Thibonnier M, Coles P, Conarty DM, Plesnicher CL, Shoham M. J Pharmacol Exp Ther. 2000 Jul;294(1):195-203.