Orexin B (human)

• Supplier: Tocris Bioscience
• Catalog: 1455
• Prices: $279.00
• Sizes: 500 µg
• Function Type: Agonist
• Cas Number: 205640-91-1
• Formula: C123H212N44O35S
• Molecular Weight: 2899.36
• Description: Endogenous agonist at orexin receptors (K i values are 420 and 36 nM for OX 1 and OX 2 receptors, respectively). Stimulates feeding following central administration and may be involved in the control of sleep-wake cycle and other hypothalamic functions. Also neuroprotective for dopaminergic neurons in rat midbrain cultures.

Product References

Orexins and orexin receptors: a family of hypothalamic neuropeptides and G - Orexins and orexin receptors: a family of hypothalamic neuropeptides and G

Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richardson JA, Kozlowski GP, Wilson S, Arch JR, Buckingham RE, Haynes AC, Carr SA, Annan RS, McNulty DE, Liu WS, Terrett JA, Elshourbagy NA, Bergsma DJ, Yanagisawa M. Cell. 1998 Feb 20;92(4):573-85.

Orexins: a new family of neuropeptides. - Orexins: a new family of neuropeptides.

Smart D. Br J Anaesth. 1999 Nov;83(5):695-7.

The hypocretin/orexin ligand-receptor system: implications for sleep and sleep - The hypocretin/orexin ligand-receptor system: implications for sleep and sleep

Kilduff TS, Peyron C. Trends Neurosci. 2000 Aug;23(8):359-65.