Org 20599

• Supplier: Tocris Bioscience
• Catalog: 3585
• Prices: $199.00, $825.00
• Sizes: 10 mg, 50 mg
• Function Type: Modulator
• Cas Number: 156685-94-8
• Chemical Name: (2β,3α,5α)-21-Chloro-3-hydroxy-2-(4-morpholinyl)pregnan-20-one
• Formula: C25H40ClNO3
• Molecular Weight: 438.04
• Description: Positive allosteric modulator and at higher concentrations direct agonist of GABA A receptors (EC 50 = 1.1 μ M). Also displays positive modulation of glycine receptors (EC 50 = 22.9 μ M). Anesthetic steroid; induces hypnosis and loss of righting reflexes in mice.

Product References

The anaesthetic action and modulation of GABAA receptor activity by the novel - The anaesthetic action and modulation of GABAA receptor activity by the novel

Hill-Venning C, Peters JA, Callachan H, Lambert JJ, Gemmell DK, Anderson A, Byford A, Hamilton N, Hill DR, Marshall RJ, Campbell AC. Neuropharmacology. 1996;35(9-10):1209-22.

Neuroactive steroids differ in potency but not in intrinsic efficacy at the - Neuroactive steroids differ in potency but not in intrinsic efficacy at the

Visser SA, Gladdines WW, van der Graaf PH, Peletier LA, Danhof M. J Pharmacol Exp Ther. 2002 Nov;303(2):616-26.

The interaction of anaesthetic steroids with recombinant glycine and GABAA - The interaction of anaesthetic steroids with recombinant glycine and GABAA

Weir CJ, Ling AT, Belelli D, Wildsmith JA, Peters JA, Lambert JJ. Br J Anaesth. 2004 May;92(5):704-11. Epub 2004 Mar 19.