Org 25543 hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 4035
• Prices: $199.00, $825.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 495076-64-7
• Chemical Name: N-[[1-(Dimethylamino)cyclopentyl]methyl]-3,5-dimethoxy-4-(phenylmethoxy)benzamidehydrochloride
• Formula: C24H32lN2O4.HCl
• Molecular Weight: 448.98
• Purity: >99 %
• Description: Potent and selective glycine transporter type 2 (GlyT2) inhibitor (IC 50 = 16 nM for hGlyT2). Displays no activity at GlyT1 or 56 other common biological targets (≥ 100 μ M), in a glycine uptake assay in CHO cells. Ameliorates mechanical allodynia after partial sciatic nerve ligation injury in mice.

Product References

The first potent and selective inhibitors of the glycine transporter type 2. - The first potent and selective inhibitors of the glycine transporter type 2.

Caulfield WL, Collie IT, Dickins RS, Epemolu O, McGuire R, Hill DR, McVey G, Morphy JR, Rankovic Z, Sundaram H. J Med Chem. 2001 Aug 16;44(17):2679-82.

Spinal antiallodynia action of glycine transporter inhibitors in neuropathic pain - Spinal antiallodynia action of glycine transporter inhibitors in neuropathic pain

Morita K, Motoyama N, Kitayama T, Morioka N, Kifune K, Dohi T. J Pharmacol Exp Ther. 2008 Aug;326(2):633-45.