Org 27569

• Supplier: Tocris Bioscience
• Catalog: 4782
• Prices: $169.00, $705.00
• Sizes: 10 mg, 50 mg
• Function Type: Modulator
• Cas Number: 868273-06-7
• Chemical Name: 5-Chloro-3-ethyl-N-[2-[4-(1-piperidinyl)phenyl]ethyl-1H-indole-2-carboxamide
• Formula: C24H28ClN3O
• Molecular Weight: 409.95
• Purity: >99 %
• Description: Potent CB 1 receptor allosteric modulator (pEC 50 = 8.24). Significantly increases binding of the CB 1 agonist [ 3 H]CP 55.940 (pK b = 5.67) and decreases binding of the CB 1 inverse agonist [ 3 H]SR 141716A (pK b = 5.95). Inhibits CB 1 receptor antagonist efficacy in vitro (pK b = 7.57).

Product References

Allosteric modulation of the cannabinoid CB1 receptor. - Allosteric modulation of the cannabinoid CB1 receptor.

Price MR, Baillie GL, Thomas A, Stevenson LA, Easson M, Goodwin R, McLean A, McIntosh L, Goodwin G, Walker G, Westwood P, Marrs J, Thomson F, Cowley P, Christopoulos A, Pertwee RG, Ross RA. Mol Pharmacol. 2005 Nov;68(5):1484-95. Epub 2005 Aug 19.

Allosterism and cannabinoid CB(1) receptors: the shape of things to come. - Allosterism and cannabinoid CB(1) receptors: the shape of things to come.

Ross RA. Trends Pharmacol Sci. 2007 Nov;28(11):567-72.