Org 48762-0

• Supplier: Tocris Bioscience
• Catalog: 4797
• Prices: $175.00, $735.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 755753-89-0
• Chemical Name: 4,6-Bis(4-fluorophenyl)-2-methyl-5-(4-pyridinyl)-2H-pyrazolo[3,4-b]pyridine
• Formula: C24H16F2N4
• Molecular Weight: 398.41
• Purity: >98 %
• Description: Selective p38 α and β kinase inhibitor (EC 50 = 0.1 μ M for p38 α ). Selective for p38 α / β over a panel of 48 other human kinases. Inhibits LPS-induced TNF α release from PBMCs. Also inhibits cytokine release in an LPS-induced endotoxemia model in mice. Orally bioavailable.

Product References

The lipase inhibitor tetrahydrolipstatin binds covalently to the putative active - The lipase inhibitor tetrahydrolipstatin binds covalently to the putative active

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Orlistat is a novel inhibitor of fatty acid synthase with antitumor activity. - Orlistat is a novel inhibitor of fatty acid synthase with antitumor activity.

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Orlistat accelerates gastric emptying and attenuates GIP release in healthy - Orlistat accelerates gastric emptying and attenuates GIP release in healthy

Enc FY, Ones T, Akin HL, Dede F, Turoglu HT, Ulfer G, Bekiroglu N, Haklar G, Rehfeld JF, Holst JJ, Ulusoy NB, Imeryuz N. Am J Physiol Gastrointest Liver Physiol. 2009 Mar;296(3):G482-9. doi: