Orphanin FQ (1-11)

Name Orphanin FQ (1-11)
Supplier Tocris Bioscience
Catalog 3540
Prices $105.00
Sizes 1 mg
Cas Number 178249-41-7
Formula C49H75N15O14
Molecular Weight 1098.2
Description Peptide fragment containing amino acids 1-11 of Nociceptin (Cat. No. 0910). Potent agonist of the ORL 1 /KOR-3 receptor (K i = 55 nM); displays no affinity for opioid receptors, including μ , δ , κ 1 and κ 3 receptors (K i >1000 nM). Displays analgesic properties in CD-1 mice.
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Product References

Structure-activity relationship studies on the novel neuropeptide orphanin FQ. - Structure-activity relationship studies on the novel neuropeptide orphanin FQ.

Reinscheid RK, Ardati A, Monsma FJ Jr, Civelli O. J Biol Chem. 1996 Jun 14;271(24):14163-8.

Pharmacological characterization of orphanin FQ/nociceptin and its fragments. - Pharmacological characterization of orphanin FQ/nociceptin and its fragments.

Rossi GC, Leventhal L, Bolan E, Pasternak GW. J Pharmacol Exp Ther. 1997 Aug;282(2):858-65.

Orphanin FQ/nociceptin analgesia in the rat. - Orphanin FQ/nociceptin analgesia in the rat.

Rossi GC, Perlmutter M, Leventhal L, Talatti A, Pasternak GW. Brain Res. 1998 May 11;792(2):327-30.