| Name | OSU 03012 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 3932 |
| Prices | $139.00, $579.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 742112-33-0 |
| Chemical Name | 2-Amino-N-[4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]acetamide |
| Formula | C26H19F3N4O |
| Molecular Weight | 460.45 |
| Purity | >98 % |
| Description | PDPK1 (PDK1) inhibitor; inhibits Akt signaling. Induces apoptosis of PC-3 and medulloblastoma cells, and inhibits growth of a number of tumor cell lines. Sensitizes radiotherapy-induced cell death and enhances cytotoxic effects of chemotherapeutic agents in vitro . Attenuates tumor growth of medulloblastoma xenografts in mice. |
| Supplier Page | Shop |
Nichols NF, Cimini MG, Haas JV, Staton BA, Tedroff J, Svensson KA. Neuropharmacology. 2002 Oct;43(5):817-24.
Natesan S, Svensson KA, Reckless GE, Nobrega JN, Barlow KB, Johansson AM, Kapur S. J Pharmacol Exp Ther. 2006 Aug;318(2):810-8. Epub 2006 Apr 28.