22-Oxacalcitriol

Name 22-Oxacalcitriol
Supplier Tocris Bioscience
Catalog 5182
Prices $189.00
Sizes 1 mg
Cas Number 103909-75-7
Chemical Name (1R,3S,5Z)-4-Methylene-5-[(2E)-2-[(1S,3aS,7aS)-octahydro-1-[(1S)-1-(3-hydroxy-3-methylbutoxy)ethyl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-1,3-cyclohexanediol
Formula C26H42O4
Molecular Weight 418.61
Purity >95 %
Description Non-calcemic vitamin D 3 (Cat. No. 4156) analog and VDR ligand. Suppresses parathyroid hormone (PTH) mRNA expression in vitro and in vivo . Exhibits similar effects to calcitriol (Cat. No. 2551) in osteoblast-like cells. Inhibits tumor growth of osteosarcoma in vitro in combination with all- trans retinoic acid.
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Product References

22-oxacalcitriol suppresses secondary hyperparathyroidism without inducing low - 22-oxacalcitriol suppresses secondary hyperparathyroidism without inducing low

Monier-Faugere MC, Geng Z, Friedler RM, Qi Q, Kubodera N, Slatopolsky E, Malluche HH. Kidney Int. 1999 Mar;55(3):821-32.

Inhibitory effects of 22-oxa-calcitriol and all- trans retinoic acid on the - Inhibitory effects of 22-oxa-calcitriol and all- trans retinoic acid on the

Barroga EF, Kadosawa T, Okumura M, Fujinaga T. Res Vet Sci. 2000 Feb;68(1):79-87.