OXF BD 02

• Supplier: Tocris Bioscience
• Catalog: 3864
• Prices: $205.00, $845.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 1429129-68-9
• Chemical Name: 3-(3,5-Dimethyl-4-isoxazolyl)-5-hydroxy-α-phenylbenzenemethanol
• Formula: C18H17NO3
• Molecular Weight: 295.33
• Purity: >98 %
• Description: Selective inhibitor of the first bromodomain of BRD4 (BRD4(1)) (IC 50 = 382 nM). Exhibits 2-3-fold selectivity for BRD4(1) over the CBP bromodomain and has little affinity for a range of other bromodomains. Reduces viability of lung adenocarcinoma cell lines and attenuates proliferation of MV-4-11 leukemia cells. Cell permeable.

Product References

3,5-dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands. - 3,5-dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands.

Hewings DS, Wang M, Philpott M, Fedorov O, Uttarkar S, Filippakopoulos P, Picaud S, Vuppusetty C, Marsden B, Knapp S, Conway SJ, Heightman TD. J Med Chem. 2011 Oct 13;54(19):6761-70.

Optimization of 3,5-dimethylisoxazole derivatives as potent bromodomain ligands. - Optimization of 3,5-dimethylisoxazole derivatives as potent bromodomain ligands.

Hewings DS, Fedorov O, Filippakopoulos P, Martin S, Picaud S, Tumber A, Wells C, Olcina MM, Freeman K, Gill A, Ritchie AJ, Sheppard DW, Russell AJ, Hammond EM, Knapp S, Brennan PE, Conway SJ. J Med Chem. 2013 Apr 25;56(8):3217-27.