(5 Z )-7-Oxozeaenol

• Supplier: Tocris Bioscience
• Catalog: 1067
• Prices: $149.00
• Sizes: 1 mg
• Function Type: Inhibitor
• Cas Number: 66018-38-0
• Chemical Name: (3S,5Z,8S,9S,11E)-3,4,9,10-tetrahydro-8,9,16-trihydroxy-14-methoxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione
• Formula: C19H22O7
• Molecular Weight: 362.37
• Purity: >99 %
• Description: Resorcyclic lactone of fungal origin that acts as a potent and selective transforming growth factor- β -activated kinase 1 (TAK1) mitogen-activated protein kinase kinase kinase (MAPKKK) inhibitor (IC 50 = 8 nM). Displays > 33-fold and > 62-fold selectivity over MEKK1 and MEKK4 respectively. Inhibits IL-1-induced activation of NF- κ B (IC 50 = 83 nM) and JNK/p38. Inhibits production of inflammatory mediators, and sensitizes cells to TRAIL- and TNF- α -induced apoptosis in vitro .

Product References

A resorcylic acid lactone, 5Z-7-oxozeaenol, prevents inflammation by inhibiting - A resorcylic acid lactone, 5Z-7-oxozeaenol, prevents inflammation by inhibiting

Ninomiya-Tsuji J, Kajino T, Ono K, Ohtomo T, Matsumoto M, Shiina M, Mihara M, Tsuchiya M, Matsumoto K. J Biol Chem. 2003 May 16;278(20):18485-90. Epub 2003 Mar 6.

Blockade of transforming growth factor-beta-activated kinase 1 activity enhances - Blockade of transforming growth factor-beta-activated kinase 1 activity enhances

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Molecular mechanisms involved in the regulation of cytokine production by muramyl - Molecular mechanisms involved in the regulation of cytokine production by muramyl

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