Ozagrel hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 1910
• Prices: $109.00, $459.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 74003-18-2
• Chemical Name: (2E)-3-[4-(1H-Imidazol-1-ylmethyl)phenyl]-2-propenoicacidhydrochloride
• Formula: C13H12N2O2.HCl
• Molecular Weight: 264.71
• Purity: >98 %
• Description: Potent and selective inhibitor of thromboxane (TXA 2 ) synthetase (IC 50 = 4 nM). Does not inhibit prostacyclin (PGI 2 ) synthetase, cyclooxygenase or PGE 2 isomerase (IC 50 > 1 mM). Inhibits platelet aggregation in vitro and arachidonate-induced arterial contraction in vivo .

Product References

Effects of thromboxane synthetase inhibitors on aggregation of rabbit platelets. - Effects of thromboxane synthetase inhibitors on aggregation of rabbit platelets.

Naito J, Komatsu H, Ujiie A, Hamano S, Kubota T, Tsuboshima M. Eur J Pharmacol. 1983 Jul 15;91(1):41-8.

Pharmacological studies on the TXA2 synthetase inhibitor - Pharmacological studies on the TXA2 synthetase inhibitor

Hiraku S, Taniguchi K, Wakitani K, Omawari N, Kira H, Miyamoto T, Okegawa T, Kawasaki A, Ujiie A. Jpn J Pharmacol. 1986 Jul;41(3):393-401.

Participation of thromboxane A(2) in the cough response in guinea-pigs: - Participation of thromboxane A(2) in the cough response in guinea-pigs:

Shinagawa K, Kojima M, Ichikawa K, Hiratochi M, Aoyagi S, Akahane M. Br J Pharmacol. 2000 Sep;131(2):266-70.