| Name | P005091 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 4485 |
| Prices | $169.00, $705.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 882257-11-6 |
| Chemical Name | 1-[5-[(2,3-Dichlorophenyl)thio]-4-nitro-2-thienyl]ethanone |
| Formula | C12H7Cl2NO3S2 |
| Molecular Weight | 348.22 |
| Purity | >99 % |
| Description | Selective inhibitor of ubiquitin-specific protease (USP) 7 (IC 50 = 4.2 μ M). Displays little-to-no inhibition of other USP variants or proteases such as caspase, cathepsins and serine proteases; exhibits some activity at USP47. Induces elevated p53 and apoptosis in cancer cell lines; displays antiangiogenic activity in vivo . |
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