P1075

• Supplier: Tocris Bioscience
• Catalog: 5127
• Prices: $189.00, $765.00
• Sizes: 10 mg, 50 mg
• Cas Number: 60559-98-0
• Chemical Name: N-cyano-N'-(1,1-dimethylpropyl)-N''-3-pyridylguanidine
• Formula: C12H17N5
• Molecular Weight: 231.3
• Purity: >99 %
• Description: Potent K ir 6 (K ATP ) channel opener (EC 50 for relaxation of rat aorta = 7.5 nM). Binds to SUR2A and SUR2B with high affinity (K d values are 17 and 3 nM respectively).

Product References

Tissue and species variation in the vascular receptor binding of 3H-P1075, a - Tissue and species variation in the vascular receptor binding of 3H-P1075, a

Higdon NR, Khan SA, Buchanan LV, Meisheri KD. J Pharmacol Exp Ther. 1997 Jan;280(1):255-60.

Stoichiometry of potassium channel opener action. - Stoichiometry of potassium channel opener action.

Gross I, Toman A, Uhde I, Schwanstecher C, Schwanstecher M. Mol Pharmacol. 1999 Dec;56(6):1370-3.

New windows on the mechanism of action of K(ATP) channel openers. - New windows on the mechanism of action of K(ATP) channel openers.

Ashcroft FM, Gribble FM. Trends Pharmacol Sci. 2000 Nov;21(11):439-45.

Pharmacological and molecular analysis of ATP-sensitive K(+) channels in the pig - Pharmacological and molecular analysis of ATP-sensitive K(+) channels in the pig

Buckner SA, Milicic I, Daza A, Davis-Taber R, Scott VE, Sullivan JP, Brioni JD. Eur J Pharmacol. 2000 Jul 21;400(2-3):287-95.