P-3F AX -Neu5Ac

• Supplier: Tocris Bioscience
• Catalog: 2244
• Prices: $185.00
• Sizes: 10 mg
• Cas Number: 117405-58-0
• Chemical Name: 5-(acetylamino)-3,5-dideoxy-3-fluoro-D-erythro-α-L-manno-2-nonulopyranosonicacidmethylester2,4,7,8,9-pentaacetate
• Formula: C22H30FNO14
• Molecular Weight: 551.47
• Purity: >97 %
• Description: Cell-permeable sialic acid analog. Deacetylation occurs intracellularly giving rise to a sialyltransferase inhibitor. Abolishes expression of SLe x expression on HL-60 cells and reduces E-selectin and P-selectin binding. Prevents metastasis formation in a mouse lung metastasis model.

Product References

Discovery of a proneurogenic, neuroprotective chemical. - Discovery of a proneurogenic, neuroprotective chemical.

Pieper AA, Xie S, Capota E, Estill SJ, Zhong J, Long JM, Becker GL, Huntington P, Goldman SE, Shen CH, Capota M, Britt JK, Kotti T, Ure K, Brat DJ, Williams NS, MacMillan KS, Naidoo J, Melito L, Hsieh J, De Brabander J, Ready JM, McKnight SL. Cell. 2010 Jul 9;142(1):39-51.

P7C3 neuroprotective chemicals function by activating the rate-limiting enzyme in - P7C3 neuroprotective chemicals function by activating the rate-limiting enzyme in

Wang G, Han T, Nijhawan D, Theodoropoulos P, Naidoo J, Yadavalli S, Mirzaei H, Pieper AA, Ready JM, McKnight SL. Cell. 2014 Sep 11;158(6):1324-34.