17-PA

• Supplier: Tocris Bioscience
• Catalog: 5086
• Prices: $239.00, $985.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 694438-95-4
• Chemical Name: 17-Phenyl-(3α,5α)-androst-16-en-3-ol
• Formula: C25H34O
• Molecular Weight: 350.54
• Purity: >99 %
• Description: Selective antagonist of neurosteroid potentiation and direct gating of GABA A receptors. Selectively reduces the effects of 5 α -reduced steroids compared to 5 β -reduced steroids and displays no effect on potentiation evoked by barbiturates and benzodiazepines. Attenuates 3 α ,5 α -THP-induced loss of righting reflex and total sleep time following i.c.v administration in rats.

Product References

Selective antagonism of 5alpha-reduced neurosteroid effects at GABA(A) receptors. - Selective antagonism of 5alpha-reduced neurosteroid effects at GABA(A) receptors.

Mennerick S, He Y, Jiang X, Manion BD, Wang M, Shute A, Benz A, Evers AS, Covey DF, Zorumski CF. Mol Pharmacol. 2004 May;65(5):1191-7.

Ethanol modulates the interaction of the endogenous neurosteroid allopregnanolone - Ethanol modulates the interaction of the endogenous neurosteroid allopregnanolone

Akk G, Li P, Manion BD, Evers AS, Steinbach JH. Mol Pharmacol. 2007 Feb;71(2):461-72. Epub 2006 Nov 14.

Antagonism of neurosteroid modulation of native gamma-aminobutyric acid receptors - Antagonism of neurosteroid modulation of native gamma-aminobutyric acid receptors

Kelley SP, Alan JK, O'Buckley TK, Mennerick S, Krishnan K, Covey DF, Leslie Morrow A. Eur J Pharmacol. 2007 Oct 31;572(2-3):94-101. Epub 2007 Jun 29.