PAC 1

• Supplier: Tocris Bioscience
• Catalog: 2681
• Prices: $139.00, $579.00
• Sizes: 10 mg, 50 mg
• Cas Number: 315183-21-2
• Chemical Name: 4-(Phenylmethyl)-1-piperazineaceticacid[[2-hydroxy-3-(2-propenyl)phenyl]methylene]hydrazide
• Formula: C23H28N4O2
• Molecular Weight: 392.5
• Purity: >98 %
• Description: Procaspase-activating compound; activates procaspase-3 to produce caspase-3 (EC 50 = 0.22 μ M). Also activates procaspase-7 in a less efficient manner (EC 50 = 4.5 μ M). Pro-apoptotic; induces apoptosis in both cancerous and non-cancerous cells dependent on procaspase-3 concentration (IC 50 values are 0.003 - 1.41 and 5.02 - 9.98 μ M respectively).

Product References

Small-molecule activation of procaspase-3 to caspase-3 as a personalized - Small-molecule activation of procaspase-3 to caspase-3 as a personalized

Putt KS, Chen GW, Pearson JM, Sandhorst JS, Hoagland MS, Kwon JT, Hwang SK, Jin H, Churchwell MI, Cho MH, Doerge DR, Helferich WG, Hergenrother PJ. Nat Chem Biol. 2006 Oct;2(10):543-50. Epub 2006 Aug 27.

Procaspase-3 activation as an anti-cancer strategy: structure-activity - Procaspase-3 activation as an anti-cancer strategy: structure-activity

Peterson QP, Hsu DC, Goode DR, Novotny CJ, Totten RK, Hergenrother PJ. J Med Chem. 2009 Sep 24;52(18):5721-31.