PACMA 31

• Supplier: Tocris Bioscience
• Catalog: 3236
• Prices: $99.00, $419.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 1401089-31-3
• Chemical Name: N-(2,4-Dimethoxyphenyl)-N-(1-oxo-2-propyn-1-yl)-2-(2-thienyl)glycylglycineethylester
• Formula: C21H22N2O6S
• Molecular Weight: 430.47
• Purity: >99 %
• Description: Irreversible protein disulfide isomerase (PDI) inhibitor; inhibits growth of ovarian cancer cells. Suppresses tumor growth in a mouse xenograph model of human ovarian cancer.

Product References

Discovery of an orally active small-molecule irreversible inhibitor of protein - Discovery of an orally active small-molecule irreversible inhibitor of protein

Xu S, Butkevich AN, Yamada R, Zhou Y, Debnath B, Duncan R, Zandi E, Petasis NA, Neamati N. Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16348-53. doi:

Small molecule probe suitable for in situ profiling and inhibition of protein - Small molecule probe suitable for in situ profiling and inhibition of protein

Ge J, Zhang CJ, Li L, Chong LM, Wu X, Hao P, Sze SK, Yao SQ. ACS Chem Biol. 2013 Nov 15;8(11):2577-85.