Paliperidone

• Supplier: Tocris Bioscience
• Catalog: 2203
• Prices: $129.00, $535.00
• Sizes: 10 mg, 50 mg
• Cas Number: 144598-75-4
• Chemical Name: 3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
• Formula: C23H27FN4O3
• Molecular Weight: 426.48
• Purity: >98 %
• Description: Atypical antipsychotic; metabolite of risperidone (Cat. No. 2865). Exhibits high affinity for 5-HT 2A receptors (K i = 0.4 nM for cloned human 5-HT 2A receptors). Also displays nanomolar affinity for human D 2 receptors.

Product References

Risperidone: a novel antipsychotic with balanced serotonin-dopamine antagonism, - Risperidone: a novel antipsychotic with balanced serotonin-dopamine antagonism,

Leysen JE, Janssen PM, Megens AA, Schotte A. J Clin Psychiatry. 1994 May;55 Suppl:5-12.

Risperidone compared with new and reference antipsychotic drugs: in vitro and in - Risperidone compared with new and reference antipsychotic drugs: in vitro and in

Schotte A, Janssen PF, Gommeren W, Luyten WH, Van Gompel P, Lesage AS, De Loore K, Leysen JE. Psychopharmacology (Berl). 1996 Mar;124(1-2):57-73.

Distinct electrophysiological effects of paliperidone and risperidone on the - Distinct electrophysiological effects of paliperidone and risperidone on the

Dremencov E, El Mansari M, Blier P. Psychopharmacology (Berl). 2007 Sep;194(1):63-72. Epub 2007 May 27.