Palmitoylethanolamide

• Supplier: Tocris Bioscience
• Catalog: 0609
• Prices: $89.00, $375.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 544-31-0
• Chemical Name: N-(2-Hydroxyethyl)hexadecanamide
• Formula: C18H37NO2
• Molecular Weight: 299.5
• Description: Endogenous lipid that acts as a selective GPR55 agonist (EC 50 values are 4, 19 800 and > 30 000 nM at GPR55, CB 2 and CB 1 receptors respectively). Substrate for fatty acid amide hydrolase (FAAH) and PEA-preferring acid amidase (PAA) and exhibits antinociceptive and anticonvulsant in vivo . Directly activates PPAR α (EC 50 = 3 μ M) producing robust anti-inflammatory actions.

Product References

Anticonvulsant activity of N-palmitoylethanolamide, a putative endocannabinoid, - Anticonvulsant activity of N-palmitoylethanolamide, a putative endocannabinoid,

Lambert DM, Vandevoorde S, Diependaele G, Govaerts SJ, Robert AR. Epilepsia. 2001 Mar;42(3):321-7.

The palmitoylethanolamide family: a new class of anti-inflammatory agents? - The palmitoylethanolamide family: a new class of anti-inflammatory agents?

Lambert DM, Vandevoorde S, Jonsson KO, Fowler CJ. Curr Med Chem. 2002 Mar;9(6):663-74.

The search for the palmitoylethanolamide receptor. - The search for the palmitoylethanolamide receptor.

LoVerme J, La Rana G, Russo R, Calignano A, Piomelli D. Life Sci. 2005 Aug 19;77(14):1685-98.

Palmitoylethanolamide, endocannabinoids and related cannabimimetic compounds in - Palmitoylethanolamide, endocannabinoids and related cannabimimetic compounds in

Re G, Barbero R, Miolo A, Di Marzo V. Vet J. 2007 Jan;173(1):21-30. Epub 2005 Dec 1.

The orphan receptor GPR55 is a novel cannabinoid receptor. - The orphan receptor GPR55 is a novel cannabinoid receptor.

Ryberg E, Larsson N, Sjogren S, Hjorth S, Hermansson NO, Leonova J, Elebring T, Nilsson K, Drmota T, Greasley PJ. Br J Pharmacol. 2007 Dec;152(7):1092-101. Epub 2007 Sep 17.