Pamoic acid disodium salt

• Supplier: Tocris Bioscience
• Catalog: 4636
• Prices: $95.00
• Sizes: 50 mg
• Function Type: Agonist
• Cas Number: 6640-22-8
• Chemical Name: 4,4'-Methylenebis(3-hydroxy-2-naphthalenecarboxylicacid)disodiumsalt
• Formula: C23H14Na2O6
• Molecular Weight: 432.33
• Purity: >99 %
• Description: GPR35 agonist. Induces GPR35 internalization and activates ERK1/2 (EC 50 values are 22 and 65 nM respectively). Mediates recruitment of β -arrestin2 to GPR35. Also exhibits antinociceptive effects in a mouse model of visceral pain.

Product References

Targeting of the orphan receptor GPR35 by pamoic acid: a potent activator of - Targeting of the orphan receptor GPR35 by pamoic acid: a potent activator of

Zhao P, Sharir H, Kapur A, Cowan A, Geller EB, Adler MW, Seltzman HH, Reggio PH, Heynen-Genel S, Sauer M, Chung TD, Bai Y, Chen W, Caron MG, Barak LS, Abood ME. Mol Pharmacol. 2010 Oct;78(4):560-8.

Antagonists of GPR35 display high species ortholog selectivity and varying modes - Antagonists of GPR35 display high species ortholog selectivity and varying modes

Jenkins L, Harries N, Lappin JE, MacKenzie AE, Neetoo-Isseljee Z, Southern C, McIver EG, Nicklin SA, Taylor DL, Milligan G. J Pharmacol Exp Ther. 2012 Dec;343(3):683-95.